Affiliation:
1. Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital Zhengzhou China
2. Department of Gastroenterology The First Affiliated Hospital of Zhengzhou University Zhengzhou China
Abstract
AbstractThe tumorigenesis of intrahepatic cholangiocarcinoma (ICC) has been identified to be exceptionally involved in dysregulated Hippo/Yes‐associated protein (YAP) signaling pathway (Hippo/YAP). Hippo/YAP functions as a master regulator engaged in a plethora of physiological and oncogenic processes as well. Therefore, the aberrant Hippo/YAP could serve as an Achilles' heel regarding the molecular therapeutic avenues for ICC patients. Herein, we comprehensively review the recent studies about the underlying mechanism of disrupted Hippo/YAP in ICC, how diagnostic values could be utilized upon the critical genes in this pathway, and what opportunities could be given upon this target pathway.