Affiliation:
1. Graduate School of Analytical Science and Technology (GRAST) Chungnam National University Daejeon Republic of Korea
Abstract
Abstractgem‐Dichloroaziridines are essential building blocks in the synthesis of biologically and pharmacologically active compounds. We developed a continuous flow biphasic system to overcome the limitation of conventional batch systems, in which dichlorocarbene generated from the reaction of chloroform and a NaOH combined with azomethines to generate gem‐dichloroaziridine derivatives in good yields. Then a two‐step one‐flow process was designed with the addition of flow synthesis of N‐benzylideneaniline. This process is also advantageous in protecting the researcher from irritating odors and harmful reactants and intermediates.