In situ biosynthetic BC/zeolite hybrid hemostat for quick clot

Abstract

AbstractZeolite‐based hemostatic agents are considered as an outstanding material to achieve rapid and definitive hemostasis in pre‐hospital management. However, developing a safer zeolitic hemostat that avoids the potential thrombotic risk caused by tiny zeolite residue in bleeding wounds remains a critical challenge. In this research, we employ an in situ biosynthesis process to fabricate a sandwich‐like structured bacterial cellulose/zeolite (BC/zeolite) hybrid hemostat. Zeolite particles were firmly bonded into the BC membranes with <1% leaching after 24 soaking. This hemostat displays effective hemostatic performance after calcium ion‐exchange process. The BC/zeolite‐Ca hemostat can significantly decrease in vitro blood clotting time from 7.5 ± 0.3 min to 2.2 ± 0.3 min. This work achieves a low‐cost, eco‐friendly, and low‐risk approach through in situ biosynthesis in the preparation of BC‐ and zeolite‐based hybrid for pre‐hospital hemostasis applications.