Cypate‐loaded hollow mesoporous Prussian blue nanoparticle/hydrogel system for efficient photodynamic therapy/photothermal therapy dual‐modal antibacterial therapy
-
Published:2023-09-20
Issue:1
Volume:112
Page:53-64
-
ISSN:1549-3296
-
Container-title:Journal of Biomedical Materials Research Part A
-
language:en
-
Short-container-title:J Biomedical Materials Res
Author:
Xing Zheng1ORCID,
Dong Bingyu1,
Zhang Xiaoxiao1,
Qiu Lin1,
Jiang Pengju1,
Xuan Yang2,
Ni Xinye3,
Xu Hongbin3,
Wang Jianhao1
Affiliation:
1. School of Pharmacy Changzhou University Changzhou Jiangsu China
2. Key Lab of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science Dalian Minzu University Dalian Liaoning China
3. Obstetrics and Gynecology Department The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou Jiangsu China
Abstract
AbstractInfectious diseases caused by pathogenic microorganisms are a significant burden on public health and the economic stability of societies all over the world. The appearance of drug‐resistant bacteria has severely blocked the effectiveness of conventional antibiotics. Therefore, developing novel antibiotic‐free strategies to combat bacteria holds huge potential for maximizing validity and minimizing the risk of enhancing bacterial resistance. Herein, a cypate‐loaded hollow mesoporous Prussian blue nanoparticles (Cy‐HMPBs) was built to achieve the PDT/PTT synergistic antimicrobial therapy. The carbomer hydrogel (CH) was combined with the Cy‐HMPBs to form a nanoparticle/hydrogel therapeutic system (Cy‐HMPBs/CH) to reach the goal of local delivery of antimicrobial cargo. The low concentration of Cy‐HMPBs/CH receives over 99% of antimicrobial ability against Escherichia coli and Staphylococcus aureus upon near‐infrared (NIR) irradiation. More importantly, Cy‐HMPBs/CH has favorable biocompatibility and can play therapeutic effects only after laser irradiation, indicating the on‐demand therapy at the targeted region to avert side effects on healthy tissue. This study provides ideas for the design of an antibiotic‐free antimicrobial strategy against infectious diseases.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Ministry of Education of China
Subject
Metals and Alloys,Biomedical Engineering,Biomaterials,Ceramics and Composites