Incidence and complications of hypothyroidism postlaryngectomy: A systematic review and meta‐analysis

Author:

Banyi Norbert1ORCID,Kwon Jamie J. Y.2,Turkdogan Sena2,Milner Thomas D.2ORCID,Prisman Eitan2ORCID

Affiliation:

1. Faculty of Medicine The University of British Columbia Vancouver British Columbia Canada

2. Division of Otolaryngology – Head and Neck Surgery, Department of Surgery Vancouver General Hospital Vancouver British Columbia Canada

Abstract

AbstractBackgroundHypothyroidism is common postlaryngectomy and is associated with laryngectomy‐specific complications. The objective of this study is to determine the incidence and predictors of hypothyroidism postlaryngectomy and its associated complications.MethodsSystematic review, data extraction, and meta‐analyses were performed following the PRISMA protocol. Six databases were searched for studies reporting on postlaryngectomy thyroid status with incidence, risk factors, management, or complications.ResultsFifty‐one studies with 6333 patients were included. The pooled incidence of postlaryngectomy hypothyroidism is 49% (CI 42%–57%). Subgroup analysis showed postlaryngectomy hypothyroidism rates significantly correlated with hemithyroidectomy and radiotherapy. Patients who underwent laryngectomy, hemithyroidectomy, and radiotherapy had a 65% (CI 59%–71%) rate of hypothyroidism; laryngectomy and hemithyroidectomy 46% (CI 33%–60%); laryngectomy and radiotherapy 26% (CI 19%–35%); and laryngectomy alone 11% (CI 4%–27%) (p < 0.001).ConclusionsLaryngectomized patients with partial thyroidectomy or radiation therapy are at significant risk of postoperative hypothyroidism. Evidence‐based protocols for early detection and (prophylactic) treatment should be established.

Publisher

Wiley

Subject

Otorhinolaryngology

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