Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms

Author:

Hayes Martin A.1ORCID,Roberts Ieuan2,Grönberg Gunnar3,Lv Kexin4,Lin Baorui4,Bergare Jonas5,Elmore Charles S.5ORCID

Affiliation:

1. Cardiovascular and Metabolic Diseases Innovative Medicines and Early Development Biotech Unit; AstraZeneca; Mölndal Sweden

2. Discovery Sciences, Innovative Medicines and Early Development Biotech Unit; AstraZeneca; Cambridgeshire UK

3. Respiratory, Inflammation & Autoimmunity, Innovative Medicines and Early Development Biotech Unit; AstraZeneca; Mölndal Sweden

4. WuXi AppTec; Shanghai China

5. Pharmaceutical Sciences Innovative Medicines and Early Development Biotech Unit; AstraZeneca; Mölndal Sweden

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference25 articles.

1. Bile acid metabolism;Danielsson;Annu Rev Biochem,1975

2. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades;Hofmann;J Lipid Res,2014

3. Bile salt biotransformations by human intestinal bacteria;Ridlon;J Lipid Res,2006

4. Hydroxylation of cholic, chenodeoxycholic, and deoxycholic acids in patients with intrahepatic cholestasis;Bremmelgaard;J Lipid Res,1980

5. Novel pathways of bile acid metabolism involving CYP3A4;Bodin;BBA-Mol Cell Biol L,1687

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