Affiliation:
1. Shams Tabrizi Clinic Tehran Iran
2. Taleghani Hospital Shahid Beheshti University of Medical Sciences and Health Services Tehran Iran
3. Department of Basic Medical Sciences Khoy University of Medical Sciences Khoy Iran
4. Department of Operating Room Khoy University of Medical Sciences Khoy Iran
5. Department of Parasitology and Mycology, School of Medicine Baqiyatallah University of Medical Sciences Tehran Iran
6. Trauma Research Center Baqiyatallah University of Medical Sciences Tehran Iran
Abstract
Key Clinical MessageGiant cell tumor of bone (GCT) is a rare neoplasm which often presents as a lytic lesion in the epiphyseal region of long bones and which are usually accompanied by pain, swelling, and restricted movement.AbstractGiant cell tumor of bone (GCT) is a rare neoplasm that affects individuals in their third and fourth decades of life. Clinically, it often presents as a lytic lesion in the epiphyseal region of bones, notably the distal femur and proximal tibia. Radiologically, GCT appears as a distinct lytic lesion in the epiphyseal region. Histopathologically, GCTs are composed of mononuclear cells, macrophages, and multinuclear giant cells, indicative of osteoclastogenic stromal tumors. A 37‐year‐old man presented with left wrist pain, swelling, and restricted movement persisting for a year, worsening over the last 7 months. Radiographic assessments revealed a distal radius bone mass involving the radiocarpal joint. Biopsy confirmed a GCT with extension into peripheral muscle. PET/CT scan showed localized pathology without metastasis. Histopathologically, GCT exhibited multinucleated giant cells, spindle cells, and aneurysmal bone cyst‐like regions with coagulation necrosis. Surgical resection involved en‐bloc removal and reconstruction with a non‐vascularized radius bone graft. Postoperatively, the patient showed no complications at the one‐year follow‐up, suggesting successful intervention.