Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle
Author:
Affiliation:
1. Cell Culture and Bioprocess Operations Department Genentech Inc. South San Francisco California USA
2. Department of Microchemistry, Proteomics and Lipidomics Genentech Inc. South San Francisco California USA
Publisher
Wiley
Subject
Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.3193
Reference37 articles.
1. Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
2. Metabolic flux analysis of CHO cell metabolism in the late non-growth phase
3. Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption
4. Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture
5. Metabolic control at the cytosol–mitochondria interface in different growth phases of CHO cells
Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. From Efficiency to Yield: Exploring Recent Advances in CHO Cell Line Development for Monoclonal Antibodies;Molecular Biotechnology;2024-02-16
2. Overexpression of peroxisome proliferator-activated receptor co-activator-1⍺ (PGC-1⍺) in Chinese hamster ovary cells increases oxidative metabolism and IgG productivity;Metabolic Engineering;2023-09
3. Chemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures;Biotechnology and Bioengineering;2023-05-06
4. CRISPR‐interceded CHO cell line development approaches;Biotechnology and Bioengineering;2023-01-12
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3