Multicenter retrospective study of the prognosis and the effect of postoperative adjuvant therapy in Japanese oral squamous cell carcinoma patients with close margin-Reference-Cited by-同舟云学术

Multicenter retrospective study of the prognosis and the effect of postoperative adjuvant therapy in Japanese oral squamous cell carcinoma patients with close margin

Published:2023-03-23 Issue:6 Volume:45 Page:1418-1429
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Hasegawa Takumi¹^ORCID,Kakei Yasumasa¹,Yamakawa Nobuhiro²^ORCID,Kirita Tadaaki²,Okura Masaya³⁴,Naruse Tomofumi⁵,Otsuru Mitsunobu⁵^ORCID,Yamada Shin‐ichi⁶⁷,Kurita Hiroshi⁶,Hirai Eiji⁸,Rin Shin⁹,Ueda Michihiro⁹,Umeda Masahiro⁵,Akashi Masaya¹^ORCID,

Affiliation:

1. Department of Oral and Maxillofacial Surgery Kobe University Graduate School of Medicine Kobe Japan

2. Department of Oral and Maxillofacial Surgery, School of Medicine Nara Medical University Kashihara Japan

3. Department of Oral and Maxillofacial Surgery Saiseikai Matsusaka General Hospital Mie Japan

4. The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry Osaka University Osaka Japan

5. Unit of Translational Medicine, Department of Clinical Oral Oncology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan

6. Department of Dentistry and Oral Surgery Shinshu University School of Medicine Matsumoto Japan

7. Department of Oral and Maxillofacial Surgery Faculty of Medicine, Academic Assembly, University of Toyama Toyama Japan

8. Department of Oral and Maxillofacial Surgery Oita Red Cross Hospital Oita Japan

9. Department of Oral Surgical Oncology Hokkaido Cancer Center Sapporo Japan

Abstract

AbstractBackgroundThe purpose of this retrospective study was to investigate the prognosis of patients with oral cavity cancer with positive margin (PM) or close margin (CM) divided into pN− and pN+ groups.MethodsThe evaluated endpoints were local control and disease‐specific survival (DSS) rates.ResultsHigher T classification, lymphovascular space invasion (LVSI), and older age were significant risk factors for DSS in the pN− groups. On the other hand, extranodal extension, multiple lymph node metastases, and LVSI were significant risk factors for DSS in the pN+ groups. Among the CM pN+ patients, no significant differences in the 3‐year DSS were observed between the only surgery (51.9%) and adjuvant groups (53.2%).ConclusionsHigher T classification and LVSI are high‐risk features more than PM or CM in the pN− groups for DSS. However, further prospective studies are needed to demonstrate the usefulness of adjuvant treatment in patients with PM or CM.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27355

Reference48 articles.

1. Current trends and future perspectives in the surgical management of oral cancer

2. Predicting the Prognosis of Oral Squamous Cell Carcinoma After First Recurrence

3. Predictors of locoregional recurrence in early stage oral cavity cancer with free surgical margins

4. Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer

5. Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck