Long‐term risk of venous thromboembolism among patients with gastrointestinal non‐neoplastic and neoplastic diseases: A prospective cohort study of 484 211 individuals

Author:

Yuan Shuai12ORCID,Sun Yuhao1,Chen Jie1,Li Xue1ORCID,Larsson Susanna C.23ORCID

Affiliation:

1. Department of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

2. Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

3. Unit of Medical Epidemiology, Department of Surgical Sciences Uppsala University Uppsala Sweden

Abstract

AbstractWe conducted a prospective cohort study to examine the associations of 21 gastrointestinal diseases with the risk of incident venous thromboembolism (VTE). The study included 485 936 UK Biobank participants free of baseline VTE. The gastrointestinal diseases were defined by the International Classification of Disease (ICD)‐9 and 10 codes with data from the nationwide inpatient data set, the primary care data set, and the cancer registries. Incident VTE cases were defined by ICD‐9 and 10 codes with data from the nationwide inpatient data set. Cox proportional hazards regression was used to estimate the associations of baseline gastrointestinal diseases with incident VTE risk. During a median follow‐up of 12.0 years, 13 646 incident VTE cases were diagnosed. Eleven gastrointestinal diseases (nine non‐neoplastic and two neoplastic) were associated with an increased risk of incident VTE after Bonferroni corrections. The risk of VTE was >50% higher among patients with gallbladder and biliary tract cancer (hazard ratio [HR] 3.15, 95% confidence interval [CI] 95% CI 1.74–5.70), pancreatic cancer (HR 2.84, 95% CI 1.65–4.91), cirrhosis (HR 2.34, 95% CI 1.96–2.79), Crohn's disease (HR 1.61, 95% CI 1.33–1.95), or pancreatitis (HR 1.57, 95% CI 1.31–1.88) compared with individuals without each of these diseases. We observed multiplicative interactions of age, sex, and body mass index with some gastrointestinal diseases (p < .05). A more pronounced, increased risk of VTE was found among younger, female, or obese patients. The study suggests a 50% higher risk of developing VTE among patients with gallbladder and biliary tract cancer, pancreatic cancer, cirrhosis, Crohn's disease, or pancreatitis.

Funder

Forskningsrådet om Hälsa, Arbetsliv och Välfärd

Karolinska Institutet

Vetenskapsrådet

Publisher

Wiley

Subject

Hematology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3