Central tolerance spares the private high-avidity CD4+T-cell repertoire specific for an islet antigen in NOD mice
Author:
Affiliation:
1. Centre de Physiopathologie de Toulouse Purpan; Toulouse France
2. INSERM; U1043 Toulouse France
3. CNRS; UMR5282 Toulouse France
4. Université Toulouse III Paul-Sabatier; Toulouse France
Funder
CNRS
Inserm
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/eji.201445290/fullpdf
Reference38 articles.
1. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus;Jolicoeur;Proc. Natl. Acad. Sci. USA,1994
2. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self;Derbinski;Nat. Immunol.,2001
3. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion;Bouneaud;Immunity,2000
4. A comprehensive guide to antibody and T-cell responses in type 1 diabetes;Lieberman;Tissue Antigens,2003
5. A defect in central tolerance in NOD mice;Kishimoto;Nat. Immunol.,2001
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