Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms

Author:

Königsberger Sebastian1,Weis Vanessa1,Prodöhl Jan1,Stehling Martin2,Hobeika Elias34,Reth Michael34,Kiefer Friedemann1ORCID

Affiliation:

1. Max Planck Institute for Molecular Biomedicine; Mammalian Cell Signaling Laboratory; Münster Germany

2. Max Planck Institute for Molecular Biomedicine; Flow Cytometry Unit; Münster Germany

3. Centre for Biological Signalling Studies (BIOSS), Faculty of Biology; University of Freiburg; Freiburg Germany

4. Max Planck Institute of Immunobiology and Epigenetics; Freiburg Germany

Funder

Deutsche Forschungsgemeinschaft

Max-Planck-Gesellschaft

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference29 articles.

1. The dissociation activation model of B cell antigen receptor triggering;Yang;FEBS Lett.,2010

2. Clustering models;Schamel;Adv. Exp. Med. Biol.,2008

3. How membrane structures control T cell signaling;Klammt;Front. Immunol.,2012

4. Autoinhibition and adapter function of Syk;Kulathu;Immunol. Rev.,2009

5. Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation;Batista;Immunol. Rev.,2010

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