Anti‐allodynic and anti‐hyperalgesic activity of (±)‐licarin A in neuropathic rats via NO‐cyclic‐GMP‐ATP‐sensitive K+ channel pathway-Reference-Cited by-同舟云学术

Anti‐allodynic and anti‐hyperalgesic activity of (±)‐licarin A in neuropathic rats via NO‐cyclic‐GMP‐ATP‐sensitive K+ channel pathway

Published:2023-11-20 Issue:1 Volume:85 Page:
ISSN:0272-4391
Container-title:Drug Development Research
language:en
Short-container-title:Drug Development Research

Author:

Hernández‐Vázquez Liliana¹^ORCID,Colín‐Martínez Brian¹,Lara‐Ruíz María Guadalupe¹,Cordova‐Alonso Beatriz¹,González‐Morales Estefanía¹^ORCID,Godínez‐Chaparro Beatriz¹^ORCID

Affiliation:

1. Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud Universidad Autónoma Metropolitana‐Xochimilco Coyoacan Mexico

Abstract

AbstractThe study aimed to examine the effect of intraperitoneal and intrathecal (±)‐licarin A in neuropathic pain induced by L5 and L6 spinal nerve ligation (SNL) in male Wistar rats and the possible involvement of the NO‐cGMP‐ATP‐sensitive K+ channel pathway. Neuropathic pain signs (allodynia and hyperalgesia) were evaluated on postoperative Day 14 using von Frey filaments. Single intraperitoneal (0.01, 0.1, 1, and 10 mg/kg) and intrathecal (0.01, 0.1, 1, and 10 µg/rat) administration of (±)‐licarin A improved allodynia and hyperalgesia. The (±)‐licarin A‐induced anti‐allodynic and anti‐hyperalgesic activity was prevented by the intrathecal injection of l‐NAME (100 µg/rat; nonselective nitric oxide synthase inhibitor), ODQ (10 µg/rat; guanylate cyclase inhibitor), and glibenclamide (50 µg/rat; adenosine triphosphate (ATP)‐sensitive K+ channel blocker). The data suggest that (±)‐licarin A exerts its anti‐allodynic and anti‐hyperalgesic activity by activating the NO‐cGMP‐ATP‐sensitive K+ channel pathway.

Publisher

Wiley

Subject

Drug Discovery

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.22134

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