Circuit topology predicts pathogenicity of missense mutations

Author:

Woodard Jaie12,Iqbal Sumaiya3456,Mashaghi Alireza17ORCID

Affiliation:

1. Medical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Faculty of Science Leiden University Leiden The Netherlands

2. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor Michigan USA

3. Center for the Development of Therapeutics Broad Institute of MIT and Harvard Cambridge Massachusetts USA

4. Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts USA

5. Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge Massachusetts USA

6. Analytic and Translational Genetics Unit Massachusetts General Hospital Boston Massachusetts USA

7. Centre for Interdisciplinary Genome Research, Faculty of Science Leiden University Leiden The Netherlands

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

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