Affiliation:
1. Department of Infectious Disease, Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou Guangdong China
2. Guangzhou Medical Research Institute of Infectious Diseases, Institution of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou Guangdong China
Abstract
AbstractFunctional cure of hepatitis B virus (HBV) is an optimal treatment goal for chronic hepatitis B, with the loss of hepatitis B surface antigen (HBsAg) being a crucial indicator. However, the adequacy of HBsAg loss for evaluating functional cure of HBV in patients co‐infected with HBV/human immunodeficiency virus (HIV) remains controversial. In this study, we measured HBV pregenomic RNA (pgRNA), a potential biomarker that correlates with covalently closed circular DNA, in the frozen plasma of 98 patients with HBsAg loss from a large HIV/HBV co‐infection cohort in Guangzhou, China. HBV pgRNA was still detected in 43.9% (44/98) of the patients, suggesting active HBV replication in individuals with HBsAg loss. Our observations imply that HBsAg loss may not be a reliable predictor of HBV functional cure in cases of HIV/HBV co‐infection.
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