Synthesis of 2‐amino‐4‐aryl‐6‐styrylpyrimidines through aza‐Michael addition/nucleophilic addition/dehydrogenation cascade reactions-Reference-Cited by-同舟云学术

Synthesis of 2‐amino‐4‐aryl‐6‐styrylpyrimidines through aza‐Michael addition/nucleophilic addition/dehydrogenation cascade reactions

Published:2023-09-17 Issue:12 Volume:60 Page:1999-2008
ISSN:0022-152X
Container-title:Journal of Heterocyclic Chemistry
language:en
Short-container-title:Journal of Heterocyclic Chem

Author:

Wang Yue¹,Li Zheng¹^ORCID

Affiliation:

1. College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou China

Abstract

AbstractAn efficient method for the synthesis of 2‐amino‐4‐aryl‐6‐styrylpyrimidines by the reactions of various distyryl ketones with guanidine hydrochloride through aza‐Michael addition/nucleophilic addition/dehydrogenation cascade processes is described. The salient features of this protocol are the use of easy‐to‐obtain substrates, transition‐metal‐free system, mild reaction conditions, high atom economy, wide substrate scope, satisfactory yield, and simple work‐up procedures.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jhet.4731

Reference44 articles.

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3. Cytotoxicity and anti-HIV evaluations of some new synthesized quinazoline and thioxopyrimidine derivatives using 4-(thiophen-2-yl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione as synthon

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5. Carbodiimide-Mediated Preparation of the Tricyclic Pyrido[3‘,2‘:4,5]pyrrolo[1,2-c]pyrimidine Ring System and Its Application to the Synthesis of the Potent Antitumoral Marine Alkaloid Variolin B and Analog

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