Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis ‐specific CD4 T‐cell phenotype regardless of HIV‐1 status

Author:

Riou Catherine12ORCID,Du Bruyn Elsa1,Ruzive Sheena1,Goliath Rene T1,Lindestam Arlehamn Cecilia S3,Sette Alessandro34,Sher Alan5,Barber Daniel L6,Wilkinson Robert J1789

Affiliation:

1. Wellcome Centre for Infectious Disease Research in Africa Institute of Infectious Disease and Molecular Medicine University of Cape Town Observatory South Africa

2. Division of Immunology Department of Pathology University of Cape Town Observatory South Africa

3. Division of Vaccine Discovery La Jolla Institute for Immunology La Jolla CA USA

4. Department of Medicine University of California San Diego La Jolla CA USA

5. Immunobiology Section Laboratory of Parasitic Diseases National Institute of Allergy and Infectious DiseasesNational Institutes of Health Bethesda MD USA

6. T Lymphocyte Biology Section Laboratory of Parasitic Diseases National Institute of Allergy and Infectious DiseasesNational Institutes of Health Bethesda MD USA

7. Department of Infectious Diseases Imperial College London London UK

8. Department of Medicine University of Cape Town Observatory South Africa

9. The Francis Crick Institute London UK

Funder

National Institutes of Health

European and Developing Countries Clinical Trials Partnership

Wellcome

Cancer Research UK

Publisher

Wiley

Subject

General Nursing,Immunology,Immunology and Allergy

Reference52 articles.

1. WHO (world health organization) Global tuberculosis report;2019.https://www.who.int/tb/publications/global_report/en/

2. UNAIDS.Global HIV & AIDS statistics ‐ 2019 fact sheet;2019.

3. Phase 2b Controlled Trial of M72/AS01EVaccine to Prevent Tuberculosis

4. Final analysis of a trial of M72/AS01E vaccine to prevent tuberculosis;Tait DR;N Engl J Med,2019

5. Drug–drug interactions and tolerance in combining antituberculosis and antiretroviral therapy

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