Radiation‐Induced Transfer of Charge, Atoms, and Energy within Isolated Biomolecular Systems

Author:

Chevalier François1,Schlathölter Thomas23,Poully Jean‐Christophe1ORCID

Affiliation:

1. CIMAP UMR 6252 CEA/CNRS/ENSICAEN/Université de Caen Normandie Bd Becquerel 14070 Caen France

2. Zernike Institute for Advanced Materials University of Groningen Groningen (The Netherlands

3. University College Groningen University of Groningen Groningen (The Netherlands

Abstract

AbstractIn biological tissues, ionizing radiation interacts with a variety of molecules and the consequences include cell killing and the modification of mechanical properties. Applications of biological radiation action are for instance radiotherapy, sterilization, or the tailoring of biomaterial properties. During the first femtoseconds to milliseconds after the initial radiation action, biomolecular systems typically respond by transfer of charge, atoms, or energy. In the condensed phase, it is usually very difficult to distinguish direct effects from indirect effects. A straightforward solution for this problem is the use of gas‐phase techniques, for instance from the field of mass spectrometry. In this review, we survey mainly experimental but also theoretical work, focusing on radiation‐induced intra‐ and inter‐molecular transfer of charge, atoms, and energy within biomolecular systems in the gas phase. Building blocks of DNA, proteins, and saccharides, but also antibiotics are considered. The emergence of general processes as well as their timescales and mechanisms are highlighted.

Funder

European Cooperation in Science and Technology

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

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