Affiliation:
1. Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOE Shandong Key Laboratory of Biochemical Analysis Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China
2. State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical Engineering Southeast University 2 Sipailou Nanjing 210096 China
Abstract
AbstractCompared with the normal assembly/disassembly approaches, enzyme‐instructed host‐guest assembly/disassembly strategies due to their superior biocompatibility and specificity for specific substrates, can more effectively and precisely release molecules at lesions for reflecting in vivo biological events. Specifically, due to the over‐expression of enzymes in specific tissues, the assembly/disassembly processes can directly occur on the pathological sites (or regions of interest), thus these enzyme‐instructed processes are widely and effectively used for disease treatment or precise bioimaging. Based on it, we introduce the concept and major strategies of enzyme‐instructed host‐guest assembly/disassembly, illustrate their importance in the diagnosis and treatment of diseases, and review their advances in biomedical applications. Further, the challenges of these strategies in the clinic and future tendencies are also prospected.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry