Forward Chemical Genetic Screen for Oxygen‐Dependent Cytotoxins Uncovers New Covalent Fragments that Target GPX4-Reference-Cited by-同舟云学术

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Forward Chemical Genetic Screen for Oxygen‐Dependent Cytotoxins Uncovers New Covalent Fragments that Target GPX4

Published:2021-07-22 Issue:1 Volume:23 Page:
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Cordon Marie B.¹^ORCID,Jacobsen Kristian M.¹^ORCID,Nielsen Cecilie S.¹^ORCID,Hjerrild Per¹^ORCID,Poulsen Thomas B.¹^ORCID

Affiliation:

1. Department of Chemistry Aarhus University Langelandsgade 140 8000 Aarhus C Denmark

Funder

Novo Nordisk Fonden

Aarhus Universitet

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.202100253

Reference31 articles.

1. Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer

2. Fragment-based covalent ligand discovery

3. Proteome-wide covalent ligand discovery in native biological systems

4. Reimagining Druggability Using Chemoproteomic Platforms

5. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

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1. Recent Progress of Glutathione Peroxidase 4 Inhibitors in Cancer Therapy;Mini-Reviews in Medicinal Chemistry;2024-06-14

2. α‐Lactam Electrophiles for Covalent Chemical Biology**;Angewandte Chemie;2023-05-15

3. α‐Lactam Electrophiles for Covalent Chemical Biology**;Angewandte Chemie International Edition;2023-05-15

4. Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery;Pharmaceuticals;2022-11-08

5. Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis;Journal of Medicinal Chemistry;2022-08-19

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