Affiliation:
1. State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China
2. Department of Experimental Medicine TOR University of Rome Tor Vergata Roma 00133 Italy
3. Suzhou Industrial Park Institute of Services Outsourcing Suzhou 215123 China
4. Department of Ultrasound Heping Hospital Affiliated to Changzhi Medical College Changzhi 046000 China
Abstract
AbstractRibonucleic acid (RNA) plays a pivotal role in gene regulation and protein biosynthesis. Interfering the physiological function of key RNAs to induce cell apoptosis holds great promise for cancer treatment. Many RNA‐targeted anti‐cancer strategies have emerged continuously. Among them, RNA interference (RNAi) has been recognized as a promising therapeutic modality for various disease treatments. Nevertheless, the primary obstacle in siRNA delivery‐escaping the endosome and crossing the plasma membrane severely impedes its therapeutic potential. Thus far, a variety of nanosystems as well as carrier‐free bioconjugation for siRNA delivery have been developed and employed to enhance the drug delivery and anti‐tumor efficiency. Besides, the use of small molecules to target specific RNA structures and disrupt their function, along with the covalent modification of RNA, has also drawn tremendous attention recently owing to high therapeutic efficacy. In this review, we will provide an overview of recent progress in RNA‐targeted cancer therapy including various siRNA delivery strategies, RNA‐targeting small molecules, and newly emerged covalent RNA modification. Finally, challenges and future perspectives faced in this research field will be discussed.
Funder
National Natural Science Foundation of China
State Key Laboratory of Radiation Medicine and Protection
Priority Academic Program Development of Jiangsu Higher Education Institutions
Subject
Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry