Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers

Author:

Tayubi Iftikhar A.1,Kumar S. Udhaya2ORCID,Doss C. George Priya2ORCID

Affiliation:

1. Department of Computer Science, Faculty of Computing and Information Technology King Abdulaziz University Rabigh Saudi Arabia

2. Laboratory of Integrative Genomics, Department of Integrative Biology, School of Bio Sciences and Technology Vellore Institute of Technology (VIT) Vellore Tamil Nadu India

Funder

King Abdulaziz University

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference51 articles.

1. K‐ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage‐independent growth than codon 13 mutation or proto‐oncogene overexpression;Guerrero S;Cancer Res,2000

2. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

3. Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors

4. First‐in‐human phase I/IB dose‐finding study of adagrasib (MRTX849) in patients with advanced KRASG12C solid tumors (KRYSTAL‐1);Ou S‐HI;J Clin Oncol.,2022

5. Sotorasib for Lung Cancers with KRAS p.G12C Mutation

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3