MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma

Author:

Tuominen Rainer1,Jewell Rosalyn2,van den Oord Joost J.3,Wolter Pascal3,Stierner Ulrika4,Lindholm Christer5,Hertzman Johansson Carolina1,Lindén Diana1,Johansson Hemming1,Frostvik Stolt Marianne1,Walker Christy2,Snowden Helen2,Newton-Bishop Julia2,Hansson Johan1,Egyházi Brage Suzanne1

Affiliation:

1. Department of Oncology and Pathology; Karolinska Institutet, Karolinska University Hospital; Stockholm Sweden

2. Leeds Institute of Cancer and Pathology, University of Leeds; Leeds United Kingdom

3. Department of General Medical Oncology; University Hospitals Leuven; Leuven Belgium

4. Department of Oncology; Sahlgrenska University Hospital; Gothenburg Sweden

5. Department of Oncology; Ryhov County Hospital; Jonkoping Sweden

Funder

Cancer Research UK

European Commission Directorate-General for Research and Innovation

Bramall Fellowship and a Medical Council Clinical Training Fellowship

Radiumhemmet Research Funds

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference36 articles.

1. Improved survival with vemurafenib in melanoma with BRAF V600E mutation;Chapman;N Engl J Med,2011

2. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations;Flaherty;N Engl J Med,2012

3. Recent advances in melanoma systemic therapy. BRAF inhibitors, CTLA4 antibodies and beyond;Menzies;Eur J Cancer,2013

4. O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry;Christmann;Biochim Biophys Acta,2011

5. Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma;Middleton;J Clin Oncol,2000

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