Rapid Information Retrieval from DNA Storage with Microfluidic Very Large‐Scale Integration Platform

Abstract

AbstractDue to its high information density, DNA is very attractive as a data storage system. However, a major obstacle is the high cost and long turnaround time for retrieving DNA data with next‐generation sequencing. Herein, the use of a microfluidic very large‐scale integration (mVLSI) platform is described to perform highly parallel and rapid readout of data stored in DNA. Additionally, it is demonstrated that multi‐state data encoded in DNA can be deciphered with on‐chip melt‐curve analysis, thereby further increasing the data content that can be analyzed. The pairing of mVLSI network architecture with exquisitely specific DNA recognition gives rise to a scalable platform for rapid DNA data reading.