Affiliation:
1. Institute of Technology University of Tartu Nooruse 1 Tartu 50411 Estonia
2. Biohybrid Materials Department of Bioproducts and Biosystems Aalto University P. O. Box 16100 Aalto 00076 Finland
3. Technical and Macromolecular Chemistry Paderborn University Warburger Str. 100 33098 Paderborn Germany
Abstract
AbstractProgrammable, custom‐shaped, and nanometer‐precise DNA origami nanostructures have rapidly emerged as prospective and versatile tools in bionanotechnology and biomedicine. Despite tremendous progress in their utilization in these fields, essential questions related to their structural stability under physiological conditions remain unanswered. Here, DNA origami stability is explored by strictly focusing on distinct molecular‐level interactions. In this regard, the fundamental stabilizing and destabilizing ionic interactions as well as interactions involving various enzymes and other proteins are discussed, and their role in maintaining, modulating, or decreasing the structural integrity and colloidal stability of DNA origami nanostructures is summarized. Additionally, specific issues demanding further investigation are identified. This review – through its specific viewpoint – may serve as a primer for designing new, stable DNA objects and for adapting their use in applications dealing with physiological media.
Funder
Emil Aaltosen Säätiö
Sigrid Juséliuksen Säätiö
Jane ja Aatos Erkon Säätiö
Suomalainen Tiedeakatemia
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
27 articles.
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