Affiliation:
1. Department of Gastric and Colorectal Surgery General Surgery Center The First Hospital of Jilin University Changchun 130021 China
2. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
3. School of Applied Chemistry and Engineering University of Science and Technology of China Hefei 230026 China
Abstract
AbstractElaborated structural modulation of Pt‐based artificial nanozymes can efficiently improve their catalytic activity and expand their applications in clinical diagnosis and biochemical sensing. Herein, a highly efficient dual‐site peroxidase mimic composed of highly dispersed Pt and Mo atoms is reported. The obtained Mo–Pt/CeO2 exhibits exceptional peroxidase‐like catalytic activity, with a Vmax as high as 34.16 × 10−8 m s−1, which is 37.5 times higher than that of the single‐site counterpart. Mechanism studies suggest that the Mo atoms can not only serve as adsorption and activation sites for the H2O2 substrate but also regulate the charge density of Pt centers to promote the generation ability of •OH. As a result, the synergistic effect between the dual active sites significantly improves the catalytic efficiency. Significantly, the application of the Mo–Pt/CeO2 catalyst's excellent peroxidase‐like activity is extended to various biochemical detection applications, including the trace detection of glucose and cysteine, as well as the assessment of antioxidants' antioxidant capacity. This work reveals the great potential of rational design dual‐site active centers for constructing high‐performance artificial nanozymes.
Funder
Industrial Innovation Funds of Jilin Province of China