Affiliation:
1. School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China
2. Department of Oncology Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China
Abstract
AbstractModern cryptography based on computational complexity theory is mainly constructed with silicon‐based circuits. As DNA nanotechnology penetrates the molecular domain, utilizing molecular cryptography for data access protection in the biomolecular domain becomes a unique approach to information security. However, building security devices and strategies with robust security and compatibility is still challenging. Here, this study reports a time‐controlled molecular authentication strategy using DNAzyme and DNA strand displacement as the basic framework. A time limit exists for authorization and access, and this spontaneous shutdown design further protects secure access. Multiple hierarchical authentications, temporal Boolean logic authentication, and enzyme authentication strategies are constructed based on DNA networks'good compatibility and programmability. This study gives proof of concept for the detection and protection of bioinformation about single nucleotide variants and miRNA, highlighting their potential in biosensing and security protection.
Funder
National Natural Science Foundation of China
Cited by
2 articles.
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