Affiliation:
1. School of Chemical Engineering Sichuan University Chengdu 610065 China
2. Department of Chemistry Washington State University Pullman WA 99164 USA
3. Department of Ophthalmology The University of Hong Kong Hong Kong 999077 China
4. Sichuan University‐Pittsburgh Institute Sichuan University Chengdu 610207 China
5. State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China
6. Department of Mechanical Engineering The University of Hong Kong Hong Kong 999077 China
Abstract
AbstractAlthough antibiotic is still the main choice for antibacteria both in hospital and community, phototherapy has become a possibly one of the alternative approaches in the treatment of microbe‐associated infections nowadays because of its considerable potential in effective eradication of pathogenic bacteria. However, overwhelming reactive oxygen species (ROS) generated from phototherapy inevitably provoke an inflammatory response, complicating the healing process. To address this outstanding issue, a MXene‐decorated nanofibrious is devised that not only yield localized heat but also elevate ROS levels under near‐infrared laser exposure ascribed to the synergistic photothermal/photodynamic effect, for potent bacterial inactivation. After being further loaded with aspirin, the nanofibrous membranes exhibit benign cytocompatibility, boosting cell growth and suppressing the (nuclear factor kappa‐B ( NF‐κB) signaling pathways through RNA sequencing analysis, indicating an excellent anti‐inflammatory effect. Interestingly, in vivo investigations also corroborate that the nanofibrous membranes accelerate infectious cutaneous regeneration by efficiently killing pathogenic bacteria, promoting collagen deposition, boosting angiogenesis, and dampening inflammatory reaction via steering NF‐κB pathway. As envisaged, this work furnishes a decorated nanofibrous membrane with programmed antibacterial and anti‐inflammatory effects for remedy of refractory bacteria‐invaded wound regeneration.
Funder
National Natural Science Foundation of China
State Key Laboratory of Polymer Materials Engineering
China Association for Science and Technology
Fundamental Research Funds for the Central Universities
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
6 articles.
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