The significance of margins in pediatric Non‐Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)-Reference-Cited by-同舟云学术

The significance of margins in pediatric Non‐Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)

Published:2023-02-06 Issue:10 Volume:12 Page:11719-11730
ISSN:2045-7634
Container-title:Cancer Medicine
language:en
Short-container-title:Cancer Medicine

Author:

Sparber‐Sauer Monika¹²^ORCID,Ferrari Andrea³,Spunt Sheri L.⁴^ORCID,Vokuhl Christian⁵,Casey Dana⁶^ORCID,Lautz Timothy B.⁷,Meyer William H.⁸,Walterhouse David O.⁹,Pajtler Kristian W.¹⁰¹¹¹²,Alaggio Rita¹³,Schmidt Andreas¹⁴,Safwat Akmal¹⁵,Timmermann Beate¹⁶,Dall'Igna Patrizia¹⁷,Chen Sonja¹⁸^ORCID,Weiss Aaron R.¹⁹,Orbach Daniel²⁰^ORCID

Affiliation:

1. Klinikum der Landeshauptstadt Stuttgart gKAöR, Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder‐, Jugend‐ und Frauenmedizin, Pädiatrie 5 (Pädiatrische Onkologie, Hämatologie, Immunologie) Stuttgart Germany

2. Medizinische Fakultät der Universität Tübingen Tübingen Germany

3. Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori Milan Italy

4. Department of Pediatrics Stanford University School of Medicine Palo Alto California United States

5. Section of Pediatric Pathology, University of Bonn Bonn Germany

6. Department of Radiation Oncology University of North Carolina School of Medicine Chapel Hill North Carolina United States

7. Division of Pediatric Surgery, Department of Surgery Northwestern University Feinberg School of Medicine Chicago Illinois United States

8. Jimmy Everest Section of Pediatric Hematology Oncology, Department of Pediatrics University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States

9. Division of Pediatric Hematology/Oncology/Stem Cell Transplant, Department of Pediatrics Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine Chicago Illinois United States

10. Hopp‐Children's Cancer Center, NCT Heidelberg (KiTZ) Heidelberg Germany

11. Division of Pediatric Neurooncology German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK) Heidelberg Germany

12. Department of Pediatric Hematology and Oncology Heidelberg University Hospital Heidelberg Germany

13. Pathology Unit, Department of Laboratories Bambino Gesù Children's Hospital, IRCCS Rome Italy

14. Department of Pediatric Surgery and Pediatric Urology University Children's Hospital, Eberhard Karls University Tuebingen Tuebingen Germany

15. Oncology Department and Danish Center for Particle Therapy Aarhus University Hospital Aarhus Denmark

16. Department of Particle Therapy University Hospital Essen, West German Proton Therapy Centre Essen (WPE), West German Cancer Center (WTZ), German Cancer Consortium (DKTK) Germany

17. Pediatric Surgery, Department of Emergencies and Organ Transplantation University of Bari Bari Italy

18. Department of Pathology and Laboratory Medicine Nationwide Children's Hospital Columbus Ohio United States

19. Department of Pediatrics Maine Medical Center Portland Maine United States

20. SIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), PSL University, Institut Curie Paris France

Abstract

AbstractBackgroundMargin status following surgery in children, adolescents, and young adults with soft tissue sarcomas is controversial and has been defined differently by various specialties, with definitions changing over time and by cooperative group. The International Soft Tissue Sarcoma Consortium (INSTRuCT) is a collaboration of the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee, European pediatric Soft Tissue sarcoma Study Group (EpSSG), and the European Cooperative Weichteilsarkom Studiengruppe (CWS) devoted to improving patient outcomes by pooling and mining cooperative group clinical trial data.MethodsThe INSTRuCT non‐rhabdomyosarcoma soft tissue sarcoma (NRSTS) working group aimed to develop international harmonized recommendations regarding surgical margin assessment and definitions in children and adolescents with soft tissue tumors.Results and ConclusionThis review addresses accepted principles and areas of controversy, including the perspectives of surgeons, pathologists, radiation oncologists, and pediatric oncologists, to develop a framework for building common guidelines for future research.

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.5671

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