Drug-metabolism mechanism: Knowledge-based population pharmacokinetic approach for characterizing clobazam drug-drug interactions
Author:
Affiliation:
1. Lundbeck LLC; Deerfield; IL USA
2. Anoixis Corporation; Natick; MA USA
Funder
Lundbeck LLC
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/jcph.603/fullpdf
Reference31 articles.
1. Deerfield, IL Lundbeck LLC 2011
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3. Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for alpha(2)- versus alpha(1)-GABA(A)-receptor complexes;Jensen;PLoS One.,2014
4. In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2 C19;Giraud;Drug Metab Dispos.,2004
5. Kinetics and metabolism of clobazam in animals and man;Volz;Br J Clin Pharmacol.,1979
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