Determination and control of low-level amino acid misincorporation in human thioredoxin protein produced in a recombinant Escherichia coli production system

Author:

Harris Robert P.,Mattocks Jo,Green Philip S.,Moffatt Frank,Kilby Peter M.

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference18 articles.

1. Prokaryotic expression of antibodies;Arbabi-Ghahroudi;Cancer Metastasis Rev,2005

2. Investigation of product microheterogeneity: A case study in rapid detection of mutation in mammalian production cell lines;Dorai;Bioprocess Int,2007

3. Assessing genetic-heterogeneity in production cell-lines-Detection by peptide-mapping of a low-level Tyr to Gln sequence variant in a recombinant antibody;Harris;Nat Biotechnol,1993

4. Effects of rare codon cluster on high-level expression of heterologous proteins in Escherichia coli;Kane;Curr Opin Biotechnol,1995

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