Evidence of a role for functional heterogeneity in multidrug resistance transporters in clinical trials of P-glycoprotein modulation in acute myeloid leukemia

Author:

Marcelletti John F.1,Sikic Branimir I.23,Cripe Larry D.4,Paietta Elisabeth5

Affiliation:

1. Department of Clinical Development; Kanisa Pharmaceuticals; San Diego California

2. Department of Medicine; Stanford University; Stanford California

3. Oncology Division; Stanford University; Stanford, California

4. Department of Hematology/Oncology; Indiana University Simon Cancer Center; Indianapolis Indiana

5. Oncology Department; Albert Einstein College of Medicine; Bronx New York

Funder

National Institutes of Health

National Cancer Institute of the National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Histology,Pathology and Forensic Medicine

Reference35 articles.

1. Molecular pathways: Regulation and therapeutic implications of multidrug resistance;Chen;Clin Cancer Res,2012

2. Drug resistance: Still a daunting challenge to the successful treatment of AML;Shaffer;Drug Resist Updat,2012

3. Mechanisms of tumor cell resistance to the current targeted-therapy agents;Khamisipour;Tumour Biol,2016

4. Disrupting P-glycoprotein function in clinical settings: What can we learn from the fundamental aspects of this transporter;Chung;Am J Cancer Res,2016

5. Coexpression of multiple ABC-transporters is strongly associated with treatment response in childhood acute myeloid leukemia;Bartholomae;Pediatr Blood Cancer,2016

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