Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression

Author:

Wang Jinheng1,De Veirman Kim1,Faict Sylvia1,Frassanito Maria Antonia2,Ribatti Domenico34,Vacca Angelo2,Menu Eline1

Affiliation:

1. Department of Hematology and Immunology, Myeloma Center Brussels; Vrije Universiteit Brussels (VUB); Brussels Belgium

2. Department of Biomedical Sciences and Human Oncology; University of Bari Medical School; Bari Italy

3. Department of Basic Medical Sciences, Neurosciences and Sensory Organs; University of Bari Medical School; Bari Italy

4. National Cancer Institute ‘Giovanni Paolo II’; Bari Italy

Funder

Fonds voor Wetenschappelijk Onderzoek (FWO-VI)

Kom op tegen Kanker (KotK)

Associazione Italiana per la Ricerca sul Cancro

Special Program Molecular Clinical Oncology 5 per 1000, Milan, Italy

European Commission's Seventh Framework Programme (EU FPT7) OVER-MyR

OPTATIO

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference55 articles.

1. Microenvironment and multiple myeloma spread;Ribatti;Thromb Res,2014

2. Immunological dysregulation in multiple myeloma microenvironment;Romano;Biomed Res Int,2014

3. The microenvironment and molecular biology of the multiple myeloma tumor;Lemaire;Adv Cancer Res,2011

4. Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis;Rajkumar;Clin Cancer Res,2002

5. Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma;Sezer;Eur J Haematol,2001

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