Affiliation:
1. Department of Structural and Functional Biology, Institute of Biosciences of Botucatu Universidade Estadual Paulista – UNESP Botucatu São Paulo Brazil
2. College of Health Science Federal University of Grande Dourados Dourados Mato Grosso do Sul Brazil
3. Center of Toxicological Assistance (CEATOX), Institute of Biosciences of Botucatu Universidade Estadual Paulista – Botucatu (UNESP) Botucatu São Paulo Brazil
Abstract
AbstractBackgroundOndansetron is a 5HT3 receptor antagonist, used to mitigate the effects of nausea and vomiting after chemotherapy or surgery. Since nausea and vomiting are common experiences during the first trimester of pregnancy, this antiemetic has been the main drug used during this period.MethodsTo evaluate the effects of ondansetron on the embryo‐fetal development, which are still very contradictory, pregnant rats were exposed to therapeutic doses of ondansetron (1.7 or 2.5 mg/kg) daily, from gestational day (GD) 6 to 15.ResultsNo clinical signs of toxicity were observed in dams during the treatment. Although the hemato‐biochemical parameters were similar among the groups, histological changes, as well as a reduction in the weight of kidney were found in the treated dams. After fetal examination, no visceral and skeletal abnormalities were observed in treated fetuses.ConclusionIn conclusion, therapeutic doses of ondansetron have low teratogenic potential in rats. These data provide important information about the drug safety during pregnancy.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Subject
Health, Toxicology and Mutagenesis,Developmental Biology,Toxicology,Embryology,Pediatrics, Perinatology and Child Health
Cited by
1 articles.
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