Affiliation:
1. Department of Physiology University of Ghana Medical School Accra Ghana
2. Department of Obstetrics and Gynaecology University of Ghana Medical School Accra Ghana
3. Department of Obstetrics and Gynaecology Korle‐Bu Teaching Hospital Accra Ghana
4. School of Nursing, College of Health Professionals and sciences University of Wisconsin‐Milwaukee Milwaukee Wisconsin USA
Abstract
AbstractBackground and AimsAlthough the understanding of pre‐eclampsia (PE) has improved, there is still insufficient knowledge on the exact etiology and pathophysiological mechanisms. Dysregulation of angiogenic factors has emerged as a significant contributing factor. Among these factors, angiopoietins (Ang‐1 and Ang‐2) have gained considerable attention due to their crucial role in regulating vascular development and endothelial function. This study explored the maternal serum levels of angiopoietins and perinatal outcomes in PE.MethodsA case‐control study involving women with PE (cases) and normotensive pregnancies (controls) was conducted at the Maternity unit of the Korle‐Bu Teaching Hospital. Descriptive analysis was performed and the Mann–Whitney U test (two‐sided) was used to compare maternal serum levels of angiopoietins between the cases and controls.ResultsWe included 188 participants comprising 94 cases (women with PE) and 94 controls (normotensive pregnancies) with an average maternal age of 29.76 ± 5.56 and 28.43 ± 5.57 years, respectively. Maternal serum levels of Ang‐2 were significantly lower among the PE cases compared to the normotensive controls (1.25 [0.90, 2.15] vs. 2.14 [1.18, 5.73] ng/mL, p = 0.001) but no significant difference in Ang‐1 levels (92.61 [80.92, 114.92] vs. 99.26 [81.76, 113.12] ng/mL, p = 0.429) was observed between the groups. The Ang‐1/Ang‐2 ratio was significantly elevated among women with PE compared to normotensive controls (74.47 [37.69, 110.59] vs. 45.98 [16.11, 88.22] ng/mL, p = 0.014). Also, women who delivered vaginally had significantly high maternal serum levels of Ang‐1 compared to women who had cesarean section delivery (107.98 ± 27.79 vs. 89.02 ± 32.62 ng/mL).ConclusionMaternal serum levels of Ang‐2 but not Ang‐1 were significantly depressed in women with PE compared to the pregnant normotensive controls. No significant associations were observed between Ang‐1, Ang‐2 levels, or the Ang‐1/Ang‐2 ratio and pregnancy outcomes such as preterm birth, birth weight, and severity of hypertension.