Overexpression of interleukin-15in vivo enhances antitumor activity against mhc class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response-Reference-Cited by-同舟云学术

Overexpression of interleukin-15in vivo enhances antitumor activity against mhc class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response

Published:2002-04-30 Issue:4 Volume:99 Page:573-578
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Int. J. Cancer

Author:

Yajima Toshiki,Nishimura Hitoshi,Wajjwalku Worawidh,Harada Mamoru,Kuwano Hiroyuki,Yoshikai Yasunobu

Publisher

Wiley

Subject

Cancer Research,Oncology

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1. The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

2. Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

3. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

4. THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

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