The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery

Author:

Hestehave Sara12,Abelson Klas S. P.1,Brønnum Pedersen Tina2,Munro Gordon3

Affiliation:

1. Department of Experimental Medicine; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark

2. H. Lundbeck A/S; Valby Denmark

3. Department of Neurology; Danish Headache Center; Glostrup Research Institute; Glostrup Copenhagen Denmark

Funder

H.Lundbeck A/S

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine

Reference81 articles.

1. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations;Andrews;Pain,2016

2. Models of nociception: Hot-plate, tail-flick, and formalin tests in rodents;Bannon;Current Protocols in Neuroscience,2007

3. Predictive validity of behavioural animal models for chronic pain;Berge;British Journal of Pharmacology.,2011

4. Time course of the distribution of morphine in brain regions and spinal cord after intravenous injection to spontaneously hypertensive and normotensive Wistar-Kyoto rats;Bhargava;Journal of Pharmacology and Experimental Therapeutics,1992

5. Sex differences in opioid analgesia, hyperalgesia, tolerance and withdrawal: Central mechanisms of action and roles of gonadal hormones;Bodnar;Hormones and Behavior,2010

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