An open-label positron emission tomography study to evaluate serotonin transporter occupancy following escalating dosing regimens of (R )-(-)-O -desmethylvenlafaxine and racemic O -desmethylvenlafaxine

Author:

Frankle W. Gordon1ORCID,Robertson Brigitte2,Maier Gary3,Paris Jennifer4,Asmonga Deanna4,May Maureen4,Himes Michael L.4,Mason N. Scott5,Mathis Chester A.5,Narendran Rajesh45

Affiliation:

1. Department of Psychiatry; NYU Langone Medical Center; New York New York

2. Shire Pharmaceuticals Inc.; Lexington Massachusetts

3. MaierMetrics and Associates, LLC; Boston Massachusetts

4. Department of Psychiatry; University of Pittsburgh; Pittsburgh Pennsylvania

5. Department of Radiology; University of Pittsburgh; Pittsburgh Pennsylvania

Funder

Sepracor, Inc.

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference42 articles.

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2. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756;Abi-Dargham;Synapse (New York, N.Y.),1999

3. High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue;Backstrom;Brain Research,1989

4. Efficacy, safety, and tolerability of fixed-dose desvenlafaxine 50 and 100 mg/day for major depressive disorder in a placebo-controlled trial;Boyer;International Clinical Psychopharmacology,2008

5. Autoradiography of antidepressant binding sites in the human brain: Localization using [3H]imipramine and [3H]paroxetine;Cortes;Neuroscience,1988

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