Development and validation of an LC–MS/MS method for the quantitative analysis of the adenosine A2a receptor antagonist NIR178 and its monohydroxy metabolite in human plasma: Application to clinical pharmacokinetics-Reference-Cited by-同舟云学术

Development and validation of an LC–MS/MS method for the quantitative analysis of the adenosine A2a receptor antagonist NIR178 and its monohydroxy metabolite in human plasma: Application to clinical pharmacokinetics

Published:2020-07-06 Issue:10 Volume:34 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Heudi Olivier¹^ORCID,Plaud Nathalie²,Aumonier Celine²,Wu Shari³,Hatsis Panos³,Hurtado Felipe K.⁴,Picard Franck¹,Winter Serge¹,Flarakos Jimmy³

Affiliation:

1. Novartis Pharma AG PK Sciences/Bioanalytics Basel Switzerland

2. SGS Saint‐Benoît France

3. Pharmacokinetic Sciences‐Safety & ADME Bioanalysis Novartis Institutes for BioMedical Research, One Health Plaza East Hanover NJ USA

4. Oncology Clinical Pharmacology Novartis Pharmaceuticals Corporation East Hanover New Jersey USA

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.4909

Reference9 articles.

1. European Medicines Agency Guideline on Bioanalytical Method Validation 2011.https://www.ema.europa.eu/documents/scientific‐guideline/guideline‐bioanalytical‐method‐validation_en.pdf

2. Guidance for Industry on Bioanalytical Method Validation. (2018)Center for Drug Evaluation and Research US Food and Drug Administration Rockville MD.https://www.fda.gov/downloads/Drugs/Guidance/ucm070107.pdf(Accessed 01.03.2018).

3. A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment

4. Critical topics in ensuring data quality in bioanalytical LC–MS method development

5. Investigation of absolute and relative response for three different liquid chromatography/tandem mass spectrometry systems; the impact of ionization and detection saturation

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