Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation-Reference-Cited by-同舟云学术

Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation

Published:2019-12-26 Issue:6 Volume:60 Page:722-733
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Liu Yuejian¹^ORCID,Badée Justine²^ORCID,Takahashi Ryan H.³,Schmidt Stephan⁴,Parrott Neil⁵,Fowler Stephen⁵,Mackenzie Peter I.⁶,Coughtrie Michael W. H.¹,Collier Abby C.¹

Affiliation:

1. Faculty of Pharmaceutical SciencesThe University of British Columbia Vancouver British Columbia Canada

2. Novartis Institutes for BioMedical Research–Translational Medicine PK Sciences–Modeling & Simulation PBPK Novartis Campus Basel Switzerland

3. Denali Therapeutics South San Francisco California USA

4. Center for Pharmacometrics & Systems PharmacologyDepartment of Pharmaceutics Lake Nona (Orlando)University of Florida Orlando Florida USA

5. Pharmaceutical SciencesRoche Pharma Research and Early DevelopmentRoche Innovation Centre Basel Basel Switzerland

6. Department of Clinical PharmacologyFlinders University of South Australia Adelaide Australia

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1571

Reference56 articles.

1. The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

2. Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases

3. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes

4. Inhibition of human and rabbit liver steroid and xenobiotic UDP-glucuronosyltransferases by tertiary amine drugs—implications for adverse drug reactions

5. The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors

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3. Population pharmacokinetics of mycophenolic acid in paediatric patients;British Journal of Clinical Pharmacology;2021-02-02

4. Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT;Biochemical and Biophysical Research Communications;2020-04