Hypoxia and its effect on the cellular system
-
Published:2024-01-27
Issue:2
Volume:42
Page:
-
ISSN:0263-6484
-
Container-title:Cell Biochemistry and Function
-
language:en
-
Short-container-title:Cell Biochemistry & Function
Author:
Rahane Dipali1,
Dhingra Tannu1,
Chalavady Guruswami1,
Datta Aishika1,
Ghosh Bijoyani1,
Rana Nikita1,
Borah Anupom2,
Saraf Shailendra1,
Bhattacharya Pallab1ORCID
Affiliation:
1. Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad Gandhinagar Gujarat India
2. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics Assam University Silchar Assam India
Abstract
AbstractEukaryotic cells utilize oxygen for different functions of cell organelles owing to cellular survival. A balanced oxygen homeostasis is an essential requirement to maintain the regulation of normal cellular systems. Any changes in the oxygen level are stressful and can alter the expression of different homeostasis regulatory genes and proteins. Lack of oxygen or hypoxia results in oxidative stress and formation of hypoxia inducible factors (HIF) and reactive oxygen species (ROS). Substantial cellular damages due to hypoxia have been reported to play a major role in various pathological conditions. There are different studies which demonstrated that the functions of cellular system are disrupted by hypoxia. Currently, study on cellular effects following hypoxia is an important field of research as it not only helps to decipher different signaling pathway modulation, but also helps to explore novel therapeutic strategies. On the basis of the beneficial effect of hypoxia preconditioning of cellular organelles, many therapeutic investigations are ongoing as a promising disease management strategy in near future. Hence, the present review discusses about the effects of hypoxia on different cellular organelles, mechanisms and their involvement in the progression of different diseases.
Funder
Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India
Indian Council of Medical Research
Subject
Cell Biology,Clinical Biochemistry,General Medicine,Biochemistry