Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants

Author:

Grinnell Steven G.12,Ansonoff Michael3,Marrone Gina F.12,Lu Zhigang1,Narayan Ankita12,Xu Jin1,Rossi Grace4,Majumdar Susruta1,Pan Ying-Xian1,Bassoni Daniel L.5,Pintar John3,Pasternak Gavril W.12

Affiliation:

1. Department of Neurology and Molecular Pharmacology and Chemistry Program; Memorial Sloan-Kettering Cancer Center; New York New York

2. Neuroscience Program, Weill Cornell Graduate School of Medical Sciences; New York New York

3. Department of Neuroscience and Cell Biology; UMDNJ-Robert Wood Johnson Medical School; Piscataway New Jersey

4. Department of Psychology, Long Island University; Post Campus Brookville New York

5. DiscoveRx Corporation; Fremont California

Funder

Commonwealth Foundation for Cancer Research

Experimental Therapeutics Center of Memorial Sloan Kettering Cancer Center

Harrington Discovery Institute

Tri-Institutional Therapeutics Discovery Institute

National Institute on Drug Abuse

National Cancer Institute

PhRMA Foundation

National Science Foundation Graduate Research Fellowship

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference60 articles.

1. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice;Abdelhamid;Journal of Pharmacology and Experimental Therapeutics,1991

2. Novel analgesics and molecular rearrangements in the morphine-thebaine group. III. Alcohols of the 6,14-endo-ethenotetrahydrooripavine series and derived analogs of N-allylnormorphine and -norcodeine;Bentley;Journal of the American Chemical Society,1967

3. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery;Bohn;Molecular Pharmacology,2004

4. Enhanced morphine analgesia in mice lacking b-arrestin 2;Bohn;Science,1999

5. Functional analysis of MOR-1 splice variants of the mu opioid receptor gene, Oprm;Bolan;Synapse,2004

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