Affiliation:
1. Bio-Organic Division Bhabha Atomic Research Centre Mumbai 400085 India
2. Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400094, India
Abstract
AbstractA fluorescent “off‐on” gamma (γ) dosimeter based on an imino‐BODIPY dye is developed. The dosimeter is highly sensitive with the lowest limit of detection (LOD, 0.001 Gy) reported so far for gamma dosimeters based on any analytical method. The dosimeter also shows colorimetric changes under γ‐exposure, which is useful for quick detection of the γ‐doses. A detailed mechanistic study was done to explain these colorimetric and fluorometric changes. Thus, the dosimeter will be useful for measuring accurate gamma‐doses in medical applications due to its high sensitivity. Interestingly, the dynamic range of the dosimeter can be tuned by changing the dye concentration. The dosimeter with 57.0 μM dye is capable of colorimetric and fluorometric measurement of 25 Gy γ‐dose, which is useful for quick and accurate measurement of absorbed γ‐doses during blood irradiation.
Funder
Department of Atomic Energy, Government of India
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Analytical Chemistry
Reference52 articles.
1.
2. G. F. Knoll Radiation Detection and Measurement Wiley New York 2010;
3. R. H. Herz The photographic action of ionizing radiations in dosimetry and medical industrial neutron auto- and microradiography Wiley-Interscience New York 1969;
4. P. B. Roberts Radiation Physics and Chemistry2014 105 78–82.
5. M. Mosayebnia M. Ahmadi M. Emzhik M. Hajiramezanali inElectromagnetic Waves-Based Cancer Diagnosis and Therapy(Eds.: M. Khafaji O. Bavi) Academic Press 2023 295–345.