Progress in the treatment of diabetic cardiomyopathy, a systematic review

Author:

Shou Yiyi1ORCID,Li Xingyu1ORCID,Fang Quan1ORCID,Xie Aqiong1ORCID,Zhang Yinghong2ORCID,Fu Xinyan3ORCID,Wang Mingwei3ORCID,Gong Wenyan13ORCID,Zhang Xingwei13ORCID,Yang Dong13ORCID

Affiliation:

1. Department of Clinical Medicine Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University Hangzhou China

2. Department of Immunology Affiliated Hospital of Hangzhou Normal University Hangzhou China

3. Department of Cardiology Affiliated Hospital of Hangzhou Normal University Hangzhou China

Abstract

AbstractDiabetic cardiomyopathy (DCM) is a condition characterized by myocardial dysfunction that occurs in individuals with diabetes, in the absence of coronary artery disease, valve disease, and other conventional cardiovascular risk factors such as hypertension and dyslipidemia. It is considered a significant and consequential complication of diabetes in the field of cardiovascular medicine. The primary pathological manifestations include myocardial hypertrophy, myocardial fibrosis, and impaired ventricular function, which can lead to widespread myocardial necrosis. Ultimately, this can progress to the development of heart failure, arrhythmias, and cardiogenic shock, with severe cases even resulting in sudden cardiac death. Despite several decades of both fundamental and clinical research conducted globally, there are currently no specific targeted therapies available for DCM in clinical practice, and the incidence and mortality rates of heart failure remain persistently high. Thus, this article provides an overview of the current treatment modalities and novel techniques pertaining to DCM, aiming to offer valuable insights and support to researchers dedicated to investigating this complex condition.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Wiley

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