Primary central nervous system lymphomas: EHA–ESMO Clinical Practice Guideline for diagnosis, treatment and follow‐up

Author:

Ferreri Andrés J. M.12,Illerhaus Gerald3,Doorduijn Jeanette K.4,Auer Dorothee P.56,Bromberg Jacoline E. C.7,Calimeri Teresa1,Cwynarski Kate8,Fox Christopher P.9,Hoang‐Xuan Khê10,Malaise Denis1112,Ponzoni Maurilio1213,Schorb Elisabeth14,Soussain Carole1516,Specht Lena17,Zucca Emanuele181920,Buske Christian21,Jerkeman Mats22,Dreyling Martin23,

Affiliation:

1. Lymphoma Unit, IRCCS San Raffaele Scientific Institute Milan Italy

2. Università Vita e Salute San Raffaele Milan Italy

3. Department of Hematology Oncology, Stem‐Cell Transplantation and Palliative Care, Klinikum Stuttgart Stuttgart Germany

4. Department of Haematology, Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands

5. Mental Health & Clinical Neurosciences Unit, School of Medicine University of Nottingham Nottingham UK

6. NIHR Nottingham Biomedical Research Centre University of Nottingham Nottingham UK

7. Department of Neuro‐Oncology, Erasmus MC Cancer Institute University Medical Center Rotterdam Rotterdam The Netherlands

8. Department of Haematology University College Hospital London UK

9. School of Medicine University of Nottingham Nottingham UK

10. Department of Neurology 2 Mazarin APHP, Groupe Hospitalier Pitié‐Salpêtrière, Sorbonne Université, ICM Paris France

11. Department of Ophthalmology Institut Curie Paris France

12. LITO, INSERM U1288, Institut Curie PSL University Orsay France

13. Pathology Unit, IRCCS San Raffaele Scientific Institute Milan Italy

14. Department of Medicine I, Medical Center, Faculty of Medicine University of Freiburg Freiburg Germany

15. Clinical Hematology Unit, Institut Curie St Cloud France

16. INSERM U932, Institut Curie PSL Research University Paris France

17. Department of Oncology, Rigshospitalet University of Copenhagen Copenhagen Denmark

18. Clinic of Medical Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale Bellinzona Switzerland

19. Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera Italiana Bellinzona Switzerland

20. Department of Medical Oncology Bern University Hospital and University of Bern Bern Switzerland

21. Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm University Hospital of Ulm Ulm Germany

22. Department of Oncology Skåne University Hospital and Lund University Lund Sweden

23. Department of Medicine III LMU University Hospital Munich Munich Germany

Abstract

Highlights This EHA‐ESMO Clinical Practice Guideline provides key recommendations for managing primary DLBCL of the CNS. The guideline covers clinical, imaging and pathological diagnosis, staging and risk assessment, treatment and follow‐up. Algorithms for first‐line and salvage treatments are provided. The author group encompasses a multidisciplinary group of experts from different institutions and countries in Europe. Recommendations are based on available scientific data and the authors' collective expert opinion.

Publisher

Wiley

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