Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the ENIGMA working groups on CNVs

Author:

Sønderby Ida E.123ORCID,Ching Christopher R. K.4ORCID,Thomopoulos Sophia I.4ORCID,Meer Dennis25,Sun Daqiang67,Villalon‐Reina Julio E.4,Agartz Ingrid8910,Amunts Katrin1112,Arango Celso1314,Armstrong Nicola J.15,Ayesa‐Arriola Rosa1416,Bakker Geor1718,Bassett Anne S.192021,Boomsma Dorret I.2223,Bülow Robin24,Butcher Nancy J.2125,Calhoun Vince D.26,Caspers Svenja1127,Chow Eva W. C.1921,Cichon Sven112829,Ciufolini Simone30,Craig Michael C.31,Crespo‐Facorro Benedicto32,Cunningham Adam C.33,Dale Anders M.3435,Dazzan Paola36,Zubicaray Greig I.37,Djurovic Srdjan138,Doherty Joanne L.3339,Donohoe Gary40,Draganski Bogdan4142,Durdle Courtney A.43,Ehrlich Stefan44,Emanuel Beverly S.45,Espeseth Thomas4647,Fisher Simon E.4849,Ge Tian5051,Glahn David C.5253,Grabe Hans J.5455,Gur Raquel E.5657,Gutman Boris A.58,Haavik Jan5960,Håberg Asta K.6162,Hansen Laura A.63,Hashimoto Ryota6465,Hibar Derrek P.66,Holmes Avram J.6768,Hottenga Jouke‐Jan22,Hulshoff Pol Hilleke E.69,Jalbrzikowski Maria70,Knowles Emma E. M.5171,Kushan Leila72,Linden David E. J.7374,Liu Jingyu2675,Lundervold Astri J.76,Martin‐Brevet Sandra41,Martínez Kenia131477,Mather Karen A.7879,Mathias Samuel R.5371,McDonald‐McGinn Donna M.458081,McRae Allan F.82,Medland Sarah E.83,Moberget Torgeir84,Modenato Claudia4185,Monereo Sánchez Jennifer738687,Moreau Clara A.88,Mühleisen Thomas W.111229,Paus Tomas8990,Pausova Zdenka91,Prieto Carlos92,Ragothaman Anjanibhargavi93,Reinbold Céline S.2994,Reis Marques Tiago3095,Repetto Gabriela M.96,Reymond Alexandre97,Roalf David R.56,Rodriguez‐Herreros Borja98,Rucker James J.36,Sachdev Perminder S.7899,Schmitt James E.100,Schofield Peter R.79101,Silva Ana I.74102,Stefansson Hreinn103,Stein Dan J.104,Tamnes Christian K.29105,Tordesillas‐Gutiérrez Diana14106,Ulfarsson Magnus O.103107,Vajdi Ariana72,Ent Dennis22,Bree Marianne B. M.33,Vassos Evangelos108,Vázquez‐Bourgon Javier1416109,Vila‐Rodriguez Fidel110,Walters G. Bragi103111,Wen Wei78,Westlye Lars T.346112,Wittfeld Katharina5455,Zackai Elaine H.4580,Stefánsson Kári103111,Jacquemont Sebastien88113,Thompson Paul M.4,Bearden Carrie E.6114,Andreassen Ole A.2,Bernard Manon,Blackburn Nicholas B.,Bøen Rune,Geus Eco,Zwarte Sonja M. C.,Forti Marta Di,Frei Oleksandr,Fukunaga Masaki,Hehir‐Kwa Jayne Y.,Hillegers Manon H. J.,Hoffmann Per,Homuth Georg,Jahanshad Neda,Koops Sanne,Kumar Kuldeep,Kikuchi Masataka,Le Hellard Stephanie,Leu Costin,Murray Robin M,Nærland Terje,Nyberg Lars,Ophoff Roel A.,Pike G Bruce,Sando Sigrid B.,Shin Jean,Shumskaya Elena,Sisodiya Sanjay M.,Steen Vidar M.,Teumer Alexander,Uhlmann Anne,Wright Margaret J.,Antshel Kevin M.,Campbell Linda E.,Crossley Nicolas A.,Crowley T. Blaine,Daly Eileen,Fiksinski Ania M.,Forsyth Jennifer K.,Fremont Wanda,Goodrich‐Hunsaker Naomi J.,Gudbrandsen Maria,Jonas Rachel K.,Kates Wendy R.,Lin Amy,McCabe Kathryn L.,Moss Hayley,Murphy Declan G.,Murphy Kieran C.,Owen Michael J.,Ruparel Kosha,Simon Tony. J.,Amelsvoort Therese,Vorstman Jacob A. S., ,

Affiliation:

1. Department of Medical Genetics Oslo University Hospital Oslo Norway

2. Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital and University of Oslo Oslo Norway

3. KG Jebsen Centre for Neurodevelopmental Disorders University of Oslo Oslo Norway

4. Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California Marina del Rey California USA

5. School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences Maastricht University Maastricht The Netherlands

6. Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Psychology University of California Los Angeles Los Angeles California USA

7. Department of Mental Health Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles California USA

8. NORMENT, Institute of Clinical Psychiatry University of Oslo Oslo Norway

9. Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

10. Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden

11. Institute of Neuroscience and Medicine (INM‐1) Research Centre Jülich Jülich Germany

12. Cecile and Oskar Vogt Institute for Brain Research, Medical Faculty University Hospital Düsseldorf, Heinrich‐Heine‐University Düsseldorf Düsseldorf Germany

13. Department of Child and Adolescent Psychiatry Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, IsSGM, Universidad Complutense, School of Medicine Madrid Spain

14. Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM) Madrid Spain

15. Mathematics and Statistics Murdoch University Perth Western Australia Australia

16. Department of Psychiatry Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute (IDIVAL) Santander Spain

17. Department of Psychiatry and Neuropsychology Maastricht University Maastricht The Netherlands

18. Department of Radiology and Nuclear Medicine VU University Medical Center Amsterdam The Netherlands

19. Clinical Genetics Research Program Centre for Addiction and Mental Health Toronto Ontario Canada

20. Dalglish Family 22q Clinic for Adults with 22q11.2 Deletion Syndrome, Toronto General Hospital University Health Network Toronto Ontario Canada

21. Department of Psychiatry University of Toronto Toronto Ontario Canada

22. Department of Biological Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands

23. Amsterdam Public Health (APH) Research Institute Amsterdam UMC Amsterdam The Netherlands

24. Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany

25. Child Health Evaluative Sciences The Hospital for Sick Children Research Institute Toronto Ontario Canada

26. Tri‐institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State, Georgia Tech, Emory Atlanta Georgia USA

27. Institute for Anatomy I Medical Faculty & University Hospital Düsseldorf, University of Düsseldorf Düsseldorf Germany

28. Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland

29. Department of Biomedicine University of Basel Basel Switzerland

30. Department of Psychosis Studies Institute of Psychiatry, Psychology and Neuroscience, King's College London London United Kingdom

31. Department of Forensic and Neurodevelopmental Sciences The Sackler Institute for Translational Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London United Kingdom

32. HU Virgen del Rocio, IBIS, Universidad de Sevilla, CIBERSAM Sevilla Spain

33. MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences Cardiff University Cardiff United Kingdom

34. Center for Multimodal Imaging and Genetics University of California San Diego La Jolla California USA

35. Department Radiology University of California San Diego La Jolla California USA

36. Department of Psychological Medicine Institute of Psychiatry, Psychology and Neuroscience, King's College London London United Kingdom

37. Faculty of Health Queensland University of Technology (QUT) Brisbane Queensland Australia

38. NORMENT, Department of Clinical Science University of Bergen Bergen Norway

39. Cardiff University Brain Research Imaging Centre (CUBRIC) Cardiff United Kingdom

40. Center for Neuroimaging, Genetics and Genomics School of Psychology, NUI Galway Galway Ireland

41. LREN, Centre for Research in Neuroscience, Department of Neuroscience University Hospital Lausanne and University Lausanne Lausanne Switzerland

42. Neurology Department Max‐Planck Institute for Human Brain and Cognitive Sciences Leipzig Germany

43. MIND Institute and Department of Psychiatry and Behavioral Sciences University of California Davis Davis California USA

44. Division of Psychological and Social Medicine and Developmental Neurosciences Faculty of Medicine, TU Dresden Dresden Germany

45. Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA

46. Department of Psychology University of Oslo Oslo Norway

47. Department of Psychology Bjørknes College Oslo Norway

48. Language and Genetics Department Max Planck Institute for Psycholinguistics Nijmegen The Netherlands

49. Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen The Netherlands

50. Psychiatric and Neurodevelopmental Genetics Unit Center for Genomic Medicine, Massachusetts General Hospital Boston Massachusetts USA

51. Department of Psychiatry, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

52. Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children's Hospital Boston Massachusetts USA

53. Department of Psychiatry Harvard Medical School Boston Massachusetts USA

54. German Center for Neurodegenerative Diseases (DZNE) Site Rostock/Greifswald Greifswald Germany

55. Department of Psychiatry and Psychotherapy University Medicine Greifswald Greifswald Germany

56. Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA

57. Youth Suicide Prevention, Intervention and Research Center Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

58. Medical Imaging Research Center, Department of Biomedical Engineering Illinois Institute of Technology Chicago Illinois USA

59. Department of Biomedicine University of Bergen Bergen Norway

60. Division of Psychiatry Haukeland University Hospital Bergen Norway

61. Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim Norway

62. Department of Radiology and Nuclear Medicine St. Olavs Hospital Trondheim Norway

63. Department of Psychiatry and Biobehavioral Sciences University of California Los Angeles Los Angeles California USA

64. Department of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Tokyo Japan

65. Department of Psychiatry Osaka University Graduate School of Medicine Osaka Japan

66. Personalized Healthcare Analytics Genentech, Inc. South San Francisco California USA

67. Department of Psychology Yale University New Haven Connecticut USA

68. Department of Psychiatry Yale University New Haven Connecticut USA

69. Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht Utrecht University Utrecht The Netherlands

70. Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA

71. Department of Psychiatry Boston Children's Hospital Boston Massachusetts USA

72. Semel Institute for Neuroscience and Human Behavior University of California Los Angeles Los Angeles California USA

73. School for Mental Health and Neuroscience Maastricht University Maastricht The Netherlands

74. Neuroscience and Mental Health Research Institute Cardiff University Cardiff United Kingdom

75. Computer Science Georgia State University Atlanta Georgia USA

76. Department of Biological and Medical Psychology University of Bergen Bergen Norway

77. Facultad de Psicología Universidad Autónoma de Madrid Madrid Spain

78. Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine University of New South Wales Sydney New South Wales Australia

79. Neuroscience Research Australia Sydney New South Wales Australia

80. Division of Human Genetics Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

81. Division of Human Genetics and 22q and You Center Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

82. Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia

83. Psychiatric Genetics QIMR Berghofer Medical Research Institute Brisbane Queensland Australia

84. Department of Psychology, Faculty of Social Sciences University of Oslo Oslo Norway

85. University of Lausanne Lausanne Switzerland

86. Faculty of Health, Medicine and Life Sciences Maastricht University Maastricht The Netherlands

87. Department of Radiology and Nuclear Medicine Maastricht University Medical Center Maastricht The Netherlands

88. Sainte Justine Hospital Research Center University of Montreal, Montreal QC Canada

89. Bloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital Toronto Ontario Canada

90. Departments of Psychology and Psychiatry University of Toronto Toronto Ontario Canada

91. Translational Medicine, The Hospital for Sick Children Toronto Ontario Canada

92. Bioinformatics Service, Nucleus University of Salamanca Salamanca Spain

93. Biomedical Engineering Oregon Health and Science University Portland Oregon USA

94. Centre for Lifespan Changes in Brain and Cognition, Department of Psychology University of Oslo Oslo Norway

95. Psychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Hammersmith Hospital Imperial College London London United Kingdom

96. Center for Genetics and Genomics Facultad de Medicina, Clinica Alemana Universidad del Desarrollo Santiago Chile

97. Center for Integrative Genomics University of Lausanne Lausanne Switzerland

98. Service de Troubles du Spectre de l'Autisme Lausanne University Hospital Lausanne Switzerland

99. Neuropsychiatric Institute The Prince of Wales Hospital Sydney New South Wales Australia

100. Department of Radiology and Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA

101. School of Medical Sciences UNSW Sydney Sydney New South Wales Australia

102. School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences Maastricht University Maastricht The Netherlands

103. Population Genomics, deCODE genetics/Amgen Reykjavik Iceland

104. SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa

105. PROMENTA Research Center, Department of Psychology University of Oslo Oslo Norway

106. Neuroimaging Unit, Technological Facilities Valdecilla Biomedical Research Institute (IDIVAL), Santander Spain

107. Faculty of Electrical and Computer Engineering University of Iceland, Reykjavik Iceland

108. Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology & Neuroscience, King's College London London United Kingdom

109. School of Medicine University of Cantabria Santander Spain

110. Department of Psychiatry The University of British Columbia Vancouver British Columbia Canada

111. Faculty of Medicine University of Iceland Reykjavik Iceland

112. NORMENT, Division of Mental Health and Addiction Oslo University Hospital Oslo Norway

113. Department of Pediatrics University of Montreal, Montreal QC Canada

114. Center for Neurobehavioral Genetics University of California Los Angeles Los Angeles California USA

Funder

National Institutes of Health

Norges Forskningsråd

Helse Sør-Øst RHF

Publisher

Wiley

Subject

Neurology (clinical),Neurology,Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Anatomy

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