Precision Reimbursement for Precision Medicine: Using Real‐World Evidence to Evolve From Trial‐and‐Project to Track‐and‐Pay to Learn‐and‐Predict

Author:

Eichler Hans‐Georg1ORCID,Trusheim Mark2ORCID,Schwarzer‐Daum Brigitte1,Larholt Kay2,Zeitlinger Markus1,Brunninger Martin3,Sherman Michael45,Strutton David6,Hirsch Gigi2ORCID

Affiliation:

1. Medical University of Vienna Vienna Austria

2. Massachusetts Institute of Technology Center for Biomedical Innovation Cambridge Massachusetts USA

3. Dachverband der Sozialversicherungsträger Vienna Austria

4. Point32Health Wellesley Massachusetts USA

5. Department of Population Medicine Harvard Medical School Boston Massachusetts USA

6. Merck & Co., Inc. Kenilworth New Jersey USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference65 articles.

1. Wartman L.&Cavallo J.O.Without genomic sequencing I would not be alive today.The ASCO Post (2018). Accessed August 2021. Story of how Washington University genetics researchers identified the gene mutation driving the ALL (acute lymphoblastic leukemia) of their colleague Dr. Lukas Wartman to repurpose a kidney cancer to put the ALL into remission (wild‐typeFLT3overexpression treated with sunitinib [Sutent]).

2. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease

3. Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

4. Randomized Controlled Trials Versus Real World Evidence: Neither Magic Nor Myth

5. Lautscham G.&Mullner S.Beyond oncology – precision medicine for autoimmune disease. Life science leader (2017). Accessed August 2021.

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