Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: Its chemical discovery and unusual binding mode

Author:

Desbordes Philippe1,Essigmann Bernd1,Gary Stephanie1,Gutbrod Oliver2,Maue Michael2ORCID,Schwarz Hans‐Georg2

Affiliation:

1. Bayer SAS Lyon France

2. Bayer AG Monheim am Rhein Germany

Publisher

Wiley

Subject

Insect Science,Agronomy and Crop Science,General Medicine

Reference12 articles.

1. Crop losses to pests

2. SchwarzHG GassmannS KuckKH Dahmen P Wachendorff‐NeumannU CarbonneSet al. FungicideN‐cyclopropyl‐sulfonylamide derivatives. World Patent WO 2007113327 (2007).

3. TiceCMandLiB N‐(heterocyclylcarbonyl)sulfonamide herbicides. US Patent US 6117821 (2000).

4. A Review of Current Knowledge of Resistance Aspects for the Next-Generation Succinate Dehydrogenase Inhibitor Fungicides

5. Based on the crystal structures of the succinate quinolate dehydrogenase (SQR) from the parasitic wormAscaris suum three‐dimensional homology models for the subunits B C and D were constructed for the respectiveZymoseptoria triticisequences using the Advanced Homology Modeling tool within the software suite Maestro followed by a subsequent energy refinement (MacroModel Minimization LBFGS method 5000 iterations) to correct for distortions and van der Waals clashes in the raw model.

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