Synthesis of New Potential Lipophilic Co‐Drugs of 2‐Chloro‐2′‐deoxyadenosine (Cladribine, 2‐CdA, Mavenclad®, Leustatin®) and 6‐Azauridine (z6U) with Valproic Acid-Reference-Cited by-同舟云学术

Synthesis of New Potential Lipophilic Co‐Drugs of 2‐Chloro‐2′‐deoxyadenosine (Cladribine, 2‐CdA, Mavenclad®, Leustatin®) and 6‐Azauridine (z6U) with Valproic Acid

Published:2019-02-25 Issue:3 Volume:16 Page:e1800497
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:C&B

Author:

Knies Christine¹,Reuter Hans²,Hammerbacher Katharina³,Bender Eugenia¹,Bonaterra Gabriel A.³,Kinscherf Ralf³,Rosemeyer Helmut¹^ORCID

Affiliation:

1. Organic Chemistry I - Bioorganic Chemistry, Institute of Chemistry of New MaterialsUniversity of Osnabrück, Barbarastr. 7 D-49069 Osnabrück Germany

2. Anorganische Chemie II, Strukturchemie, Institute of Chemistry of New MaterialsUniversity of Osnabrück Barbarastr. 7, D-49069 Osnabrück Germany

3. Institute for Anatomy and Cell Biology, Department of Medical Cell BiologyPhilipps-University of Marburg Robert-Koch-Str. 8 D-35032 Marburg Germany

Funder

NMR measurements by Mrs. M. Gather Steckhan

HR-ESI-MS measurements by Dr. S. Walter

elemental analyses by Mrs. A. Schuster

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.201800497

Reference59 articles.

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3. L. F. Christensen A. D. Broom M. J. Robins A. Bloch ‘Synthesis and Biological Activity of Selected 2 6-Disubstituted-(2-deoxy-α- and -β-D-erythro-pentofuranosyl)purines’ J. Med. Chem.1972 15 735–739.

4. Z. Kazimierczuk H. B. Cottam G. R. Revankar R. K. Robins ‘Synthesis of 2′-Deoxytubercidin 2′-Deoxyadenosine and Related 2′-Deoxynucleosides via a Novel Direct Stereospecific Sodium Salt Glycosylation Procedure’ J. Am. Chem.1984 106 6379–6382.

5. Z. Kazimierczuk J. Vilpo C. Hildebrand G. Wright ‘Synthesis and Cytotoxicity of Deoxyadenosine Analogues: Isomer Distribution in the Sodium Salt Glycosylation of 2 6-Disubstituted Purines’ J. Med. Chem.1990 33 1683–1687.

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