Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint-Reference-Cited by-同舟云学术

Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint

Published:2019-08-28 Issue:21 Volume:20 Page:2747-2751
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Schupfner Michael¹,Busch Florian²,Wysocki Vicki H.²,Sterner Reinhard¹^ORCID

Affiliation:

1. Institute of Biophysics and Physical BiochemistryUniversity of Regensburg Universitätsstraße 31 93053 Regensburg Germany

2. Department of Chemistry and Biochemistry andResource for Native Mass Spectrometry Guided Structural BiologyThe Ohio State University 473 W 12th Ave Columbus OH 43210 USA

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.201900323

Reference24 articles.

2. Modelling the evolution of the archeal tryptophan synthase

3. Gene rearrangements in the evolution of the tryptophan synthetic pathway

4. Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex

5. Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation

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